College football Week 6 picks, odds and top 25 betting report

The big Week 5 showdown between Georgia and Alabama came down to a wild fourth quarter and finish for the Crimson Tide. Alabama built a 21-0 lead in the first quarter but lost it within the final three minutes. A 75-yard touchdown strike from new Heisman Trophy favorite Jalen Milroe to Ryan Williams seconds later put 'Bama back on top and they were able to hold onto their 41-34 victory. This win also moved Alabama to No. 1 in this week's AP Top 25 poll, followed by Texas, Ohio State, Tennessee and Georgia, as fans closely monitor the viewing and betting action as the upcoming college games unfold. Football playoffs with 12 teams decide.

But beyond the dominance of the SEC and Big Ten, which took 12 of the top 13 spots in this week's Top 25 poll, UNLV broke into the AP Top 25 for the first time in program history. That's quite a turnaround in two years for a Las Vegas program that has been among the worst in college football for decades and remains in the Mountain West while five other schools, including No. 21 Boise State, leaving the MWC to the new Pac 12 in 2026.

College football's week six schedule beginning in October includes only one Top 25 matchup.

FanDuel is the official odds provider for The Associated Press, which selects voters for the AP poll of sports reporters covering college football across the country.

AP Top 25 Week 6 Matchups and Odds

College football Opportunities from FanDuel Sportsbook are updated regularly and are subject to change, including props and live betting. All times East and betting favorites (-) listed. Check back for more tips and ATS notes.

Friday, October 4th

• No. 6 Oregon (-24.5) vs. Michigan State | 9 p.m. | FOX
• No. 25 UNLV (-6.5) vs. Syracuse at | 9 p.m. | FS1

Saturday, October 5th

• No. 1 Alabama (-23.5) at Vanderbilt | 4:15 | SEC Network
• No. 2 Texas | Bye
• No. 3 Ohio State (-20.5) vs. Iowa | 3:30 p.m. | CBS – I bet Iowa
• No. 4 Tennessee (-13.5) at Arkansas | 7:30 p.m. | ABC
• No. 5 Georgia (-24.5) vs. Auburn | 3:30 p.m. | ABC/ESPN+
• No. 7 Penn State (-27.5) vs. UCLA | 12 p.m. | FOX
• No. 8 Miami (-10.5) in California | 10:30 p.m. | ESPN
• No. 9 Missouri at No. 25 Texas A&M (-2.5) | 12 p.m. | ABC/ESPN+
• No. 10 Michigan at Washington (-2.5) | 7:30 p.m. | NBC
• No. 11 Southern California (-8.5) at Minnesota | 7:30 p.m. | BTN
• No. 12 Ole Miss (-9.5) at South Carolina | 3:30 p.m. | ESPN
• No. 13 LSU | Bye
• No. 14 Notre Dame | Bye
• No. 15 Clemson (-14.5) at Florida State | 7 p.m. | ESPN
• No. 16 Iowa State (-12.5) vs. Baylor | 7:30 p.m. | FOX
• No. 17 BYU | Bye
• #18 Utah | Bye
• No. 19 Oklahoma | Bye
• No. 20 Kansas State | Bye
• No. 21 Boise State (-26.5) vs. Utah State | 7 p.m. | FOX
• No. 22 Louisville (-6.5) vs. SMU| 12 p.m. | ESPN
• No. 23 Indiana (-13.5) at Northwestern | 3:30 p.m. | BTN
• No. 24 Illinois | Bye

Get more votes: Arizona 106, Pittsburgh 42, Nebraska 30, Boston College 18, Iowa 17, James Madison 13, Oklahoma State 8, South Carolina 8, Rutgers 7, Kentucky 6, Navy 6, SMU 4, Army 2, Colorado 1.

Notable Line Moves Week 6

Circa Sports in Las Vegas opens weekly college football lines on Sunday mornings following each week's NCAA football games. Here are the notable line changes with updates on FanDuel.

• Georgia -20 to -24.5
• Penn State -24 to -27.5
• Tennessee -11 to -13.5
• Boise State -24 to -26.5

Next week's key top 25 games include:

• Texas (-14.5) vs. Oklahoma
• Ohio State (-2.5) at Oregon
• Ole Miss (-3.5) at LSU
• Penn State (-2.5) at USC

There are more big watch and betting actions coming up on October 19th, with Georgia vs. Texas (-2.5) and Alabama (-2.5) vs. Tennessee.

You can bet on it.

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