College Football 2024 Week 6 – Top 25 Betting Odds, Lines

Week 6 of the 2024 college football season is highlighted by a Friday night doubleheader featuring ranked teams and a series of conference games. Michigan State travels to Eugene to face No. 6 Oregon in Big Ten play for the first time. Oregon will look to keep the momentum going ahead of an important Week 7 game with No. 3 Ohio State.

Meanwhile, No. 25 UNLV, which just earned its first win without former quarterback Matthew Sluka, faces former Buckeye Kyle McCord and Syracuse. Saturday's slate includes No. 9 Missouri and No. 25 Texas A&M (12 p.m. ET on ABC/ESPN+).

Finally, there's an ACC nightcap as Cam Ward and No. 8 Miami travel to Berkley for the first time to face California (10:30 p.m. ET on ESPN).

Here are all the odds and odds for games featuring the top 25 teams in Week 6.

All odds are correct as of the time stamp. For the latest odds, visit ESPN BET.

Michigan State at No. 6 Oregon (-24)
Friday, 9 p.m. ET, FOX

Records: Michigan State 3-2; Oregon 4-0
Opening line: Oregon -24.5, O/U 52.5
Money line: Michigan State (+1200); Oregon (-2500)
Over/Under: 52.5 (O-110, U 110)

FPI projection Oregon with a 22.7 point lead, 92% chance of winning the game

Syracuse at No. 25 UNLV (-6.5)
Friday, 9 p.m. ET, FS1

Records: Syracuse 3-1; UNLV 4-0
Opening line: UNLV -4.5, O/U 57.5
Money line: Syracuse (+195); UNLV (-230)
Over/Under: 58.5 (O-105, U-115)

FPI projection UNLV by 12.5 points, 79% chance of winning the game

UCLA at No. 7 Penn State (-28)
Saturday, 12pm ET, FOX

Records: UCLA 1-3; Penn State 4-0
Opening line: Penn State -27.5, O/U 45.5
Money line: UCLA (+1800); Penn State (-4000)
Over/Under: 46.5 (O-110, U 110)

FPI projection Penn State with a 27.3 point lead, 95% chance of winning the game

No. 9 Missouri (-2.5) at No. 25 Texas A&M
Saturday, noon ET, ABC, ESPN+

Records: Missouri 4-0; Texas A&M 4-1
Opening line: Texas A&M -2, O/U 49.5
Money line: Missouri (+110); Texas A&M (-130)
Over/Under: 48.5 (O-110, U 110)

FPI projection Missouri by 0.7 points, 52% chance of winning the game

SMU at No. 22 Louisville (-7)
Saturday, noon ET, ESPN

Records: SMU 4-1; Louisville 3-1
Opening line: Louisville -7, O/U 58.5
Money line: SMU (+210); Louisville (-250)
Over/Under: 56.5 (O-110, U-110)

FPI projection Louisville with a 6.6 point lead, 67% chance of winning the game

Iowa at No. 3 Ohio State (-20.5)
Saturday, 3:30 p.m. ET, CBS, Paramount+

Records: Iowa 3-1; Ohio State 4-0
Opening line: Ohio State -23.5, O/U 42.5
Money line: Iowa (+900); Ohio State (-1600)
Over/Under: 44.5 (O-115, U-105)

FPI projection Ohio State with a 19.6 point lead, 90% chance of winning the game

Auburn at No. 5 Georgia (-24)
Saturday, 3:30 p.m. ET, ABC, ESPN+

Records: Auburn 2-3; Georgia 3:1
Opening line: Georgia -27, O/U 49.5
Money line: Auburn (+1200); Georgia (-2500)
Over/Under: 53.5 (O-105, U-115)

FPI projection Georgia with a 21.1 point lead, 91% chance of winning the game

No. 12 Ole Miss (-9) at South Carolina
Saturday, 3:30 p.m. ET, ESPN

Records: Ole Miss 4-1; South Carolina 3-1
Opening line: Ole Miss -10, O/U 51.5
Money line: Ole Miss (-340); South Carolina (+270)
Over/Under: 53.5 (O-110, U-110)

FPI projection Ole Miss by 10.3 points, 75% chance of winning the game

No. 23 Indiana (-13) in Northwestern
Saturday, 3:30 p.m. ET, Big Ten Network

Records: Indiana 5-0; Northwest 2-2
Opening line: Indiana -13, O/U 43.5
Money line: Indiana (-600); Northwest (+450)
Over/Under: 41.5 (O-110, U-110)

FPI projection Indiana with a 15.8 point lead, 85% chance of winning the game

No. 1 Alabama (-23) at Vanderbilt
Saturday, 4:15 p.m. ET, SEC Network

Records: Alabama 4-0; Vanderbilt 2-2
Opening line: Alabama -24.5, O/U 55.5
Money line: Alabama (-1800); Vanderbilt (+1000)
Over/Under: 55.5 (O-105, U-115)

FPI projection Alabama with a 22.3 point lead, 92% chance of winning the game

No. 15 Clemson (-14.5) at Florida State
Saturday, 7 p.m. ET, ESPN

Records: Clemson 3-1; Florida State 1-4
Opening line: Clemson -15.5, O/U 46.5
Money line: Clemson (-700); Florida State (+500)
Over/Under: 47.5 (O-115, U-105)

FPI projection Clemson with a 12.6 point lead, 80% chance of winning the game

Utah State at No. 21 Boise State (-27)
Saturday, 7 p.m. ET, FS2

Records: Utah State 1-3; Boise State 3-1
Opening line: Boise State -28, O/U 65.5
Money line: Utah State (+1500); Boise State (-3500)
Over/Under: 66.5 (O-110, U-110)

FPI projection Boise State with a 30.1 point lead, 97% chance of winning the game

No. 4 Tennessee (-13.5) at Arkansas
Saturday, 7:30 p.m. ET, ABC, ESPN+

Records: Tennessee 4-0; Arkansas 3-2
Opening line: Tennessee -13.5, O/U 60.5
Money line: Tennessee (-525); Arkansas (+400)
Over/Under: 59.5 (O-110, U-110)

FPI projection Tennessee with a 14 point lead, 82% chance of winning the game

No. 10 Michigan at Washington (-2.5)
Saturday, 7:30 p.m. ET, NBC, Peacock

Records: Michigan 4-1; Washington 3-2
Opening line: Washington -2.5, O/U 41.5
Money line: Michigan (+115); Washington (-135)
Over/Under: 41.5 (O-105, U-115)

FPI projection Washington with a 2.9 point lead, 58% chance of winning the game

No. 11 USC (-8) in Minnesota
Saturday, 7:30 p.m. ET, Big Ten Network

Records: USC 3-1; Minnesota 2-3
Opening line: USC -9.5, O/U 51.5
Money line: USC (-320); Minnesota (+260)
Over/Under: 51.5 (O STRAIGHT, U -120)

FPI projection USC with an 8.4 point lead, 71% chance of winning the game

Baylor at No. 16 Iowa State (-11.5)
Saturday, 7:30 p.m. ET, FOX\

Records: Baylor 2-3; Iowa State 4-0
Opening line: Iowa State -12.5, O/U 46.5
Money line: Baylor (+380); Iowa State (-500)
Over/Under: 44.5 (O-115, U-105)

FPI projection Iowa State with a 10.9 point lead, 77% chance of winning the game

No. 8 Miami (-10.5) in California
Saturday, 10:30 p.m. ET, ESPN

Records: Miami 5-0; California 3-1
Opening line: Miami -13.5, O/U 55.5
Money line: Miami (-400); California (+320)
Over/Under: 54.5 (O-110, U-110)

FPI projection Miami with an 8.5 point lead, 72% chance of winning the game