Lanes are closed following a multi-vehicle crash on southbound Highway 101 in San Francisco

According to the California Highway Patrol, a multi-vehicle collision impacted traffic on southbound US Highway 101 in San Francisco on Wednesday afternoon.

As of 4:30 p.m., a multi-vehicle crash involving a box truck blocked lanes 2 through 5 south of the Cesar Chavez Street on-ramp, CHP said.

A box truck was thrown onto its side. A photo released by CHP showed officers along with emergency responders at the scene of the accident.

Just before 6 p.m., CHP said the three right southbound lanes of US-101 remained closed just south of the Cesar Chavez Street on-ramp while crews worked to remove the overturned box truck.

Authorities said the estimated time for all southbound lanes to reopen was approximately 6:30 p.m. Motorists are advised to use alternative routes and avoid the area.